Tag Archives: Postpartum

Does Exercise During Pregnancy Prevent Postpartum Depression?

While there is some data to indicate that exercise may improve well-being and diminish symptoms of depression and anxiety, the results have been mixed.  A recent randomized controlled trial has explored the efficacy of exercise during pregnancy for reducing the risk of postpartum depression. The Physical Activity for Mothers Enrolled in Longitudinal Analysis (PAMELA) Study… Read More »

FDA Supports Intravenous Brexanolone for Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed with moderate to severe postpartum depression. This… Read More »

New Study at CWMH: Genetics of Postpartum Psychosis – Massachusetts General Hospital Postpartum Psychosis Project (MGHP3)

Postpartum psychosis (PPP) is a rare but serious condition, occurring in 1 to 2 per 1000 women in the weeks after delivery and associated with extreme delirium-like behavior, delusions, hallucinations, and an increased risk of suicide and infanticide.[1] While there appears to be a strong link between postpartum psychosis and bipolar disorder,[2] it is estimated… Read More »